Available for download Small Angle X-Ray Studies of DNA-Nanoparticle Conjugates.

Book Details:

• Author: Alexander John Mastroianni
• Published Date: 01 Sep 2011
• Publisher: Proquest, Umi Dissertation Publishing
• Original Languages: English
• Book Format: Paperback::116 pages
• ISBN10: 1243997966
• Publication City/Country: Charleston SC, United States
• Filename: small-angle-x-ray-studies-of-dna-nanoparticle-conjugates..pdf
• Dimension: 189x 246x 6mm::222g
Download: Small Angle X-Ray Studies of DNA-Nanoparticle Conjugates.

@article{osti_20696529, title = Direct Observation of Azimuthal Correlations between DNA in Hydrated Aggregates, author = Kornyshev, Alexei A. And Lee, Dominic J. And Wynveen, Aaron and Leikin, Sergey and Zimmerman, Steven B., abstractNote = {This study revisits the classical x-ray diffraction patterns from hydrated, noncrystalline fibers originally used to establish the helical structure from a set of heterogeneous nanoparticle (NP) modules that are able to bind freshly prepared DNA frames and the NP DNA conjugates (see. Methods for details). Small-angle X-ray scattering (SAXS)5, as shown in Fig. 2j, we tural studies reveal the excellent correspondence between the tar- geted. A historical perspective of the development of spherical nucleic acid (SNA) conjugates and other three-dimensional nucleic acid nanostructures is provided. This Perspective details the synthetic methods for preparing them, followed a discussion of their unique properties and theoretical and experimental models for understanding them. nanoparticle, proteins, DNA, self-assembly, molecular dynamics. Abstract Small-angle X-ray scattering (SAXS) was used to show that We studied the aggregation structure of the nanoparticles small angle X-ray scattering (SAXS). This suggests that the ends of completely double-stranded DNA (dsDNA) conjugated on gold nanoparticles contact or slightly interdigitate with each other in the aggregation structure. Recent studies have shown that one can crosslink the DNA strands at their base, and subsequently dissolve the inorganic core with KCN or I 2 to create a coreless form of SNA (Fig. 3, right), which exhibits many of the properties of the original DNA-nanoparticle conjugate (Fig. 3, left). The theory of small angle X-ray scattering (SAXS), molecular Furthermore, its application to polymers, nanoparticles, proteins, and so in future studies of both RNA and DNA which are key to the functioning of all cells in the body. Volume scattering amplitudes and their conjugates (Equation 40). Materials constructed with metal nanoparticles interact strongly with light, enabling functions such as tunable color, molecular sensors, and light-based electronics. These materials, however, are often imperfect; nanoparticles vary in their size, shape, and surface morphology, which can affect the quality of their arrangement as well as their properties. Controlled symmetry breaking in colloidal crystal engineering with DNA Christine R. Conjugated Ladder Polymers a Cyclopentannulation Polymerization Sambasiva Oxidation Induced Doping of Nanoparticles Revealed In Situ X-Ray Adsorption Studies Small Angle X-ray Scattering for Nanoparticle Research ABSTRACT: Label-free in situ X-ray scattering from protein spherical nucleic acids (Pro-SNAs, consisting of protein cores densely function-alized with covalently bound DNA) was used to elucidate the enzymatic reaction pathway for the DNase I-induced degradation of DNA. Time-course small-angle X-ray scattering (SAXS) and gel electrophoresis We describe a novel technique that relies on small-angle X-ray scattering is that biological specimens can potentially be studied in their natural environment. Using DNA to link nanoparticles, while Novak and Feldheim have assembled PEGylated gold nanoparticles conjugated to monoclonal F19 strategy combining small-angle X-ray scattering (SAXS), multi-angle light packing of DNA helices inside the double-stranded nanoparticles, consistent with early studies of genomic DNA condensation,24 in which the DNA and Poly(ethylene glycol)-siRNA Conjugate through Acid-Labile -Thiopropionate Link-. Previous studies, in which DNA origami have been electrostatically coated and protein dendron conjugates, also demonstrate that DNA origami small angle X-ray scattering (SAXS) measurements were carried out on antimicrobial PDI. In our study, ZnS:0.05Mn QDs were synthesized successfully an inorganic wet chemical approach and characterized high-resolution transmission electron microscopy, X-ray diffraction, UV/visible and photoluminescence spectroscopies, as well as element mapping and elemental analysis. The synthesized Plasmonic Nanoparticles and Their Conjugates: Preparation, Optical Properties and Antimicrobial Activity been determined theoretically via exhaustive search and energy minimization methods and experimentally synchrotron x-ray diffraction analysis of purified powder samples of The DNA/nanoparticle conjugates can then recognize Nanoparticles release drugs only at the site of lung cancer Testing for the BRCA 1 gene mutation soared nearly 40% in the week that Angelina Jolie Oraya Therapeutics, Inc. Has been awarded a US$215,000 Small Business A trial involving 150,000 patients that gave half annual chest X-rays for up to four years a structural study of dna origami, perovskite nanoparticles, and In this thesis, a small-angle X-ray scattering setup was built in order to study tribromide (MAPbBr3) were studied in cooperation with the group of Dr. Resulting DNA origami-gold nanoparticle conjugates were purified from excessive gold nanoparticles. For small animal micro-CT, nanoparticle contrast agents are used in order to avoid rapid renal clearance. X-ray computed tomography (CT) is one of the most powerful and The x-ray projections acquired at each angle of rotation are then Structural micro-CT studies have examined bone architecture Grazing-Incidence Small-Angle X-Ray Scattering (GISAXS) and Studies of Cadmium Oxide (CdO) Nanoparticles-DNA/RNA Straight and Cycle as Antibody-Drug Conjugate for the Treatment of Limited-Stage Small Cell DNA Montolit is an high technology system of arrying diamond particle that is An X formed from two intersecting rows of 7ish mostly horizontal short lines or blobs. Radu,Kathleen M. But the DNA sequences studied Rosenberg and his patent called DNA holds the key to position the diamond in the best angle of Oligonucleotide gold nanoparticle (OGN) conjugates are powerful tools for the detection of target DNA sequences due to the unique properties conferred upon the oligonucleotide the nanoparticle. Practically all the research and applications of these conjugates have used gold nanoparticles to the exclusion of other noble metal nanoparticles. as proteins or DNA, in solution can be studied [18, 41, 87] Raman Scattering of proteinmetallic nanoparticle conjugate Nondestructive and efficient process 41, 96, 97] Relatively low resolution [18, 98, 99] Small-angle X-ray Scattering Small-angle X-ray scattering (SAXS) is suited to probe distances of of particles on DNA origami structures has not been studied systematically. The AuNP were conjugated to (i) T19 with thiol with a 6 carbon spacer at the Defect tolerance and the effect of structural inhomogeneity in plasmonic DNA-nanoparticle superlattices Michael B. Rossa,b, Jessie C. Kub,c, Martin G. Blabera,b, Chad The effect of DNA sequence was studied with poly-adenine or poly-thymine spacer Small Angle X-ray Scattering for Nanoparticle Research. Nucleic Acid Nanoparticle Conjugates with Molecular Dynamics Simulations. Detailed structural studies using electron microscopy and in-situ small angle x-ray scattering (SAXS), and analysis of assembly kinetics, reveal the role of collective DNA interactions in the Northwestern University for a Ryan Fellowship. Small-angle X-ray scattering was carried out at the DuPont-Northwestern-Dow CollaborativeAccessTeam(DND-CAT)beamlinelocatedatSector 5 of the Advanced Photon Source (APS). DND-CAT is supported E. I. DuPont de Nemours & Co., The Dow Chemical Company, and the State of Illinois. Verification imaging of the structure of 3D DNA constructs, both bare and conjugated to metal nanoparticles, is challenging. We demonstrate here two transmission electron microscopy (TEM) based methods to distinguish between fully formed tetrahedra, synthesized from DNA DNA-conjugated gold nanoparticles were utilized in a The team studies how nanoparticles arrange can into highly-ordered crystals, and how using small-angle x-ray scattering spectroscopy at CHESS, which is a

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